epistemology


Episode 67: Fever on the Frontier

In the early 19th century, a strange new illness, seemingly unknown to medicine, ravaged settler communities in the American Middle West. As fierce debates about this new disease, now called milk sickness, raged – was it from toxic swamp gasses? arsenic in the soil? infectious microorganisms? from the poor constitutions […]


Diagnosing Diagnosis: A Historical and Epistemological Exploration of the Internist’s Most Important Procedure

  What does it mean to make a diagnosis? Are we always talking about the same thing? If you couldn’t make the lecture in person, here is a recording of the Grand Rounds I gave this year at Beth Israel Deaconess Medical Center where I explore the changing definitions of diagnosis […]


Episode 50: I Know Nothing

  What does it mean to know something in medicine? In this episode, we’ll explore this question by developing a historical framework of medical epistemologies in a journey that involves King Nebuchadnezzar, citrus fruit, leeches, water pumps, ICD-10, Socrates, skepticism, and 1970’s computer programs designed to replace doctors. This is […]


Episode 47: The Criteria

  Can we ever know what causes a chronic disease? In this episode, I’m joined again by Dr. Shoshana Herzig to finish a three-part miniseries on Bradford Hill and Doll’s attempts to prove that smoking caused lung cancer. We’ll talk about the first prospective cohort trial in history, 1960s “Fake […]